Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations.

作者: Norbert Hájos , István Katona , SS Naiem , Ken Mackie , Catherine Ledent

DOI: 10.1046/J.1460-9568.2000.00217.X

关键词: NeuroscienceInhibitory postsynaptic potentialInterneuronGABAergicCell biologyAgonistBiologyGlutamatergicKainic acidReceptorHippocampal formation

摘要: … These experiments imply that the major site of action of cannabinoids will be on GABAergic … receptors in the modulation of GABAergic transmission and to determine how cannabinoids …

参考文章(38)
Zoltan Nusser, Norbert Hájos, Peter Somogyi, Istvan Mody, Increased number of synaptic GABA A receptors underlies potentiation at hippocampal inhibitory synapses Nature. ,vol. 395, pp. 172- 177 ,(1998) , 10.1038/25999
Xiao-Jing Wang, György Buzsáki, Gamma Oscillation by Synaptic Inhibition in a Hippocampal Interneuronal Network Model The Journal of Neuroscience. ,vol. 16, pp. 6402- 6413 ,(1996) , 10.1523/JNEUROSCI.16-20-06402.1996
Istvan Katona, Beata Sperlagh, Attila Sık, Attila Käfalvi, E Sylvester Vizi, Ken Mackie, Tamas F Freund, Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons The Journal of Neuroscience. ,vol. 19, pp. 4544- 4558 ,(1999) , 10.1523/JNEUROSCI.19-11-04544.1999
M Herkenham, AB Lynn, MR Johnson, LS Melvin, BR de Costa, KC Rice, Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study The Journal of Neuroscience. ,vol. 11, pp. 563- 583 ,(1991) , 10.1523/JNEUROSCI.11-02-00563.1991
Dinah L. Misner, Jane M. Sullivan, Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 Neurons The Journal of Neuroscience. ,vol. 19, pp. 6795- 6805 ,(1999) , 10.1523/JNEUROSCI.19-16-06795.1999
W. Twitchell, S. Brown, K. Mackie, Cannabinoids Inhibit N- and P/Q-Type Calcium Channels in Cultured Rat Hippocampal Neurons Journal of Neurophysiology. ,vol. 78, pp. 43- 50 ,(1997) , 10.1152/JN.1997.78.1.43
Robert E. Hampson, Sam A. Deadwyler, Role of cannabinoid receptors in memory storage. Neurobiology of Disease. ,vol. 5, pp. 474- 482 ,(1998) , 10.1006/NBDI.1998.0223
Zoltan Nusser, Rafael Lujan, Gregor Laube, J.David B Roberts, Elek Molnar, Peter Somogyi, Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus Neuron. ,vol. 21, pp. 545- 559 ,(1998) , 10.1016/S0896-6273(00)80565-6
Ryuichi Shigemoto, Yoshifumi Nakaya, Sakashi Nomura, Reiko Ogawa-Meguro, Hitoshi Ohishi, Takeshi Kaneko, Shigetada Nakanishi, Noboru Mizuno, Immunocytochemical localization of rat substance P receptor in the striatum Neuroscience Letters. ,vol. 153, pp. 157- 160 ,(1993) , 10.1016/0304-3940(93)90311-8
M. G. Nunzi, A. Gorio, F. Milan, T. F. Freund, P. Somogyi, A. D. Smith, Cholecystokinin-immunoreactive cells form symmetrical synaptic contacts with pyramidal and nonpyramidal neurons in the hippocampus The Journal of Comparative Neurology. ,vol. 237, pp. 485- 505 ,(1985) , 10.1002/CNE.902370406