Detection of Drug-Resistant Minority Variants of HIV-1 During Virologic Failure of Indinavir, Lamivudine, and Zidovudine
作者： Carrie Dykes , Joe Najjar , Ronald J. Bosch , Michael Wantman , Manohar Furtado
DOI: 10.1086/382033
关键词: Lamivudine/Zidovudine 、 Context (language use) 、 Indinavir 、 Proteolytic enzymes 、 Drug resistance 、 Lamivudine 、 Biology 、 Virology 、 Zidovudine 、 Lentivirus 、 Immunology
摘要: We evaluated zidovudine-experienced patients for whom treatment with indinavir, lamivudine, and zidovudine failed, indinavir-resistant minority variants. Of 10 plasma human immunodeficiency virus type 1 RNA suppression subsequent rebound, 6 without primary indinavir-resistance mutations underwent clonal analysis. One had evidence of V82A in 9 30 clones at week 24, no increase 40. The dominant week-40 82V-M184V changes protease codons 62-64, compared all 24 Resistance to indinavir can emerge during failure nucleoside-experienced but may be missed by routine sequence Selection variants on occur slowly, depending the genetic context which they arise.
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