Chemokine Signaling in T-Lymphocyte Migration: The Role of Phosphoinositide 3-kinase

摘要: The biochemical events that are elicited upon chemokine engagement have been a major focus of interest in many cell types responding to plethora different chemokines. We now appreciate collectively, chemokines can couple wide range signals including phosphoinositide lipid metabolism, elevation intracellular calcium levels, and activation array protein kinases as well small GTPases. Chemokine signaling particularly studied T lymphocytes where the ordered directional migration is key process development, immune surveillance, responses. These cells therefore offer splendid model system which understand activated by their functional importance. One most robust several members 3-kinase (PI3K) family. In systems, PI3Ks known contribute aspects migratory machinery gradient sensing, signal amplification, actin reorganization hence motility. This chapter will on role PI3K-dependent T-lymphocyte points at these may integrate with other effectors cascades.