2P domain K+ channels: novel pharmacological targets for volatile general anesthetics.
作者： Amanda J. Patel , Eric Honore
DOI: 10.1007/978-1-4419-9280-2_2
关键词: Halothane 、 Potassium channel 、 Hyperpolarization (biology) 、 Chemistry 、 GABAA receptor 、 Neuron 、 Membrane potential 、 Chloride channel 、 Aplysia 、 Stereochemistry
摘要: Volatile anesthetics induce neuron hyperpolarization and consequent depression of the central nervous system (Nicoll Madison, 1982; Berg- Johnsen Langmoen, 1987; Franks Lieb, 1988; el-Beheiry Puil, 1989; Southan Wann, Maclver Kendig, 1991; 1994; Harris et al, 1995; Belelli 1999; Sirois 2000). Besides well known potentiation GABAA glycine chloride channels (Harris 1999), evidence demonstrates that in both vertebrates invertebrates, volatile open background K thus increase resting membrane potential (Franks Winegar 1996; Lopes 1998; For instance, mollusc Lymnea, halothane opens a class baseline K+ (IKAn) which hyperpolarize silence pacemaker neurons 1998). In Aplysia californica, halothane-mediated neuronal is due to opening S type (serotonin-sensitive) channel (Winegar 1996). Similarly, acid-sensitive K+channels by produces rat hypoglossal locus coeruleus (Sirois
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