White Matter Hyperintensities Quantification in Healthy Adults: A Systematic Review and Meta-Analysis

摘要: Background Although white matter hyperintensities (WMH) volumetric assessment is now customary in research studies, inconsistent WMH measures among homogenous populations may prevent the clinical usability of this biomarker. Purpose To determine whether a point estimate and reference standard for volume healthy aging population could be determined. Study Type Systematic review meta-analysis. Population In all, 9716 adult subjects from 38 studies reporting were retrieved following systematic search on EMBASE. Field Strength/Sequence 1.0T, 1.5T, or 3.0T/fluid-attenuated inversion recovery (FLAIR) and/or proton density/T2-weighted fast spin echo sequences gradient T1-weighted sequences. Assessment After literature search, sample size, demographics, magnetic field strength, MRI sequences, level automation assessment, study population, extracted. Statistical Tests The pooled with 95% confidence interval (CI) was calculated using random-effect model. The I2 statistic as measure heterogeneity across studies. Meta-regression analysis age performed. Results Of analyzed, 17 reported mean deviation (SD) included meta-analysis. Mean SD 66.11 ± 10.92 years (percentage men 50.45% ± 21.48%). Heterogeneity very high (I2 = 99%). 4.70 cm3 (95% CI: 3.88–5.53 cm3). At meta-regression analysis, positively associated subjects' (β 0.358 cm3 per year, P < 0.05, R2 0.27). Data Conclusion lack standardization definition together technical variability explain large component observed heterogeneity. Currently, volumes are not comparable between an Level Evidence 1 Technical Efficacy Stage 1