piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis

作者: Wee Siong Sho Goh , Ilaria Falciatori , Oliver H. Tam , Ralph Burgess , Oliver Meikar

DOI: 10.1101/GAD.260455.115

关键词: GeneGerm cellTransposable elementBiologyGene silencingPsychological repressionPiwi-interacting RNAMiWiGeneticsMeiosis

摘要: MIWI catalytic activity is required for spermatogenesis, indicating that piRNA-guided cleavage is critical for germ cell development. To identify meiotic piRNA targets, we …

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