Structure and function of poly(A) binding proteins.
作者： Uwe Kühn , Elmar Wahle
DOI: 10.1016/J.BBAEXP.2004.03.008
关键词: RNA 、 Processivity 、 Cytoplasm 、 Biology 、 Plasma protein binding 、 Poly(A)-binding protein 、 Biochemistry 、 Biophysics 、 Poly(A)-Binding Protein II 、 Poly(A)-Binding Protein I 、 Translation (biology)
摘要: Poly (A) tails are found at the 3' ends of almost all eukaryotic mRNAs. They bound by two different poly binding proteins, PABPC in cytoplasm and PABPN1 nucleus. functions initiation translation regulation mRNA decay. In both functions, an interaction with m7G cap 5' end message plays important role. is involved synthesis tails, increasing processivity polymerase contributing to defining length a newly synthesized tail.
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sci-hub.se 参考文章(200)
R. Eckner, W. Ellmeier, M.L. Birnstiel, Mature mRNA 3' end formation stimulates RNA export from the nucleus. The EMBO Journal. ,vol. 10, pp. 3513- 3522 ,(1991) , 10.1002/J.1460-2075.1991.TB04915.X
S. Bienroth, W. Keller, E. Wahle, Assembly of a processive messenger RNA polyadenylation complex The EMBO Journal. ,vol. 12, pp. 585- 594 ,(1993) , 10.1002/J.1460-2075.1993.TB05690.X
W. Nietfeld, H. Mentzel, T. Pieler, The Xenopus laevis poly(A) binding protein is composed of multiple functionally independent RNA binding domains. The EMBO Journal. ,vol. 9, pp. 3699- 3705 ,(1990) , 10.1002/J.1460-2075.1990.TB07582.X
S. Z. Tarun, A. B. Sachs, Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G. The EMBO Journal. ,vol. 15, pp. 7168- 7177 ,(1996) , 10.1002/J.1460-2075.1996.TB01108.X
M. Wormington, A. M. Searfoss, C. A. Hurney, Overexpression of poly(A) binding protein prevents maturation-specific deadenylation and translational inactivation in Xenopus oocytes. The EMBO Journal. ,vol. 15, pp. 900- 909 ,(1996) , 10.1002/J.1460-2075.1996.TB00424.X
Joel D. Richter, 27 Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function Cold Spring Harbor Monograph Archive. ,vol. 39, pp. 785- 805 ,(2000) , 10.1101/087969618.39.785
John WB Hershey, Michael Mathews, Nahum Sonenberg, None, Translational control of gene expression Cold Spring Harbor Laboratory Press. ,(2000)
Thomas Preiss, Matthias W. Hentze, Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast Nature. ,vol. 392, pp. 516- 520 ,(1998) , 10.1038/33192
J. Lingner, I. Radtke, E. Wahle, W. Keller, Purification and characterization of poly(A) polymerase from Saccharomyces cerevisiae Journal of Biological Chemistry. ,vol. 266, pp. 8741- 8746 ,(1991) , 10.1016/S0021-9258(18)31508-4
Alan B. Sachs, Gabriele Varani, Eukaryotic translation initiation: there are (at least) two sides to every story. Nature Structural & Molecular Biology. ,vol. 7, pp. 356- 361 ,(2000) , 10.1038/75120