Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents

作者: Hiromichi Tanaka , Hideaki Takashima , Masaru Ubasawa , Kouichi Sekiya , Issei Nitta

DOI: 10.1021/JM00103A009

关键词: StereochemistryThymineChemical synthesisUracilChemistryBenzyl CompoundsLactamAlkylationMethyl groupIsopropyl

摘要: The effect of substitution in the acyclic structure of 1-[(2-hydroxyethoxy) methyl]-6-(phenylthio)-thymine (HEPT) on anti-HIV-1 activity was investigated by synthesizing a series of deoxy …

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