Antiretroviral therapies in HIV-1 infection.

摘要: Recent progress in our understanding of the viral dynamics and immunobiology HIV infection, coupled with introduction a new generation antiretroviral agents, has led to significant advances medical management infection. Eleven drugs are currently licensed United States, eight Europe. These include nucleoside reverse transcriptase inhibitors (AZT, ddI, ddC, 3TC d4T); non-nucleoside (nevirapine delavirdine) protease (saquinavir, indinavir ritonavir). This report summarises recent developments use therapies main treatment strategies under evaluation current trials. novel agents; combinations achieve maximal suppression; optimal sequencing subtraction therapy. However, many important issues remain unre...