Comparative study of Chinese hamster ovary cell versus Escherichia coli-derived bone morphogenetic protein-2 using the critical-size supraalveolar peri-implant defect model.
作者： Jaebum Lee , Eui Nam Lee , James Yoon , Sung-Min Chung , Hari Prasad
关键词: Craniofacial 、 Long bone 、 Escherichia coli 、 Implant 、 In vitro 、 Biology 、 Andrology 、 Chinese hamster ovary cell 、 Anatomy 、 Bone morphogenetic protein 2 、 Surgical mesh
摘要: Background: Chinese hamster ovary (CHO) cell-derived recombinant human bone morphogenetic protein-2 (rhBMP-2) has been introduced for spine, long bone, and craniofacial indications. Escherichia coli- (E. coli) derived rhBMP-2 displays comparable efficacy to CHO in vitro small-animal models. The objective of this study is evaluate the E. coli-derived compared benchmark using an established large-animal model.Methods: Contralateral, critical-size supraalveolar peri-implant defects six adult male Hound Labrador mongrel dogs received cell- or (0.2 mg/mL) absorbable collagen sponge (ACS) carrier. In each quadrant, three dental implants were placed. A titanium mesh device was used support space provision. animals fluorescent markers qualitative evaluations. Animals euthanized at 8 weeks histopathologic histometric evaluation.Results: Clinical healing inclu...
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Sascha A. Jovanovic, Dennis R. Hunt, George W. Bernard, Hubertus Spiekermann, Russell Nishimura, John M. Wozney, Ulf M. E. Wikesjö, Long-term functional loading of dental implants in rhBMP-2 induced bone. A histologic study in the canine ridge augmentation model. Clinical Oral Implants Research. ,vol. 14, pp. 793- 803 ,(2003) , 10.1046/J.0905-7161.2003.CLR140617.X
John F. Decker, Jaebum Lee, Carlo Alberto Cortella, Giuseppe Polimeni, Michael D. Rohrer, John M. Wozney, Jan Hall, Cristiano Susin, Ulf M.E. Wikesjö, Evaluation of Implants Coated With Recombinant Human Bone Morphogenetic Protein-2 and Vacuum-Dried Using the Critical-Size Supraalveolar Peri-Implant Defect Model in Dogs Journal of Periodontology. ,vol. 81, pp. 1839- 1849 ,(2010) , 10.1902/JOP.2010.100220
H. DANIEL ZEGZULA, DAVID C. BUCK, JOHN BREKKE, JOHN M. WOZNEY, JEFFREY O. HOLLINGER, Bone Formation With Use of rhBMP-2 (Recombinant Human Bone Morphogenetic protein-2) Journal of Bone and Joint Surgery, American Volume. ,vol. 79, pp. 1778- 1790 ,(1997) , 10.2106/00004623-199712000-00003
Gertrud C. Hötten, Tomoaki Matsumoto, Michio Kimura, Rolf F. Bechtold, Renate Kron, Takane Ohara, Hideyuki Tanaka, Yusuke Satoh, Makoto Okazaki, Takuhiro Shirai, Haiou Pan, Shinji Kawai, Jens S. Pohl, Akira Kudo, Recombinant Human Growth/Differentiation Factor 5 Stimulates Mesenchyme Aggregation and Chondrogenesis Responsible for the Skeletal Development of Limbs Growth Factors Journal. ,vol. 13, pp. 65- 74 ,(1996) , 10.3109/08977199609034567
Ulf M. E. Wikesjö, Mohammed Qahash, Giuseppe Polimeni, Cristiano Susin, Richard H. Shanaman, Michael D. Rohrer, John M. Wozney, Jan Hall, Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein‐2: histologic observations Journal of Clinical Periodontology. ,vol. 35, pp. 1001- 1010 ,(2008) , 10.1111/J.1600-051X.2008.01321.X
Ulf M. E. Wikesjö, Cristiano Susin, Mohammed Qahash, Giuseppe Polimeni, Knut N. Leknes, Richard H. Shanaman, Hari S. Prasad, Michael D. Rohrer, Jan Hall, The critical-size supraalveolar peri-implant defect model: characteristics and use. Journal of Clinical Periodontology. ,vol. 33, pp. 846- 854 ,(2006) , 10.1111/J.1600-051X.2006.00985.X
Huiman X. Barnhart, Michael J. Haber, Lawrence I. Lin, An Overview on Assessing Agreement with Continuous Measurements Journal of Biopharmaceutical Statistics. ,vol. 17, pp. 529- 569 ,(2007) , 10.1080/10543400701376480
Jung Kiu Chai, Chang Sung Kim, Ui Won Jung, Seong Ho Choi, Youna Choi, Jeong Ho Yun, Sinus augmentation using absorbable collagen sponge loaded with Escherichia coli-expressed recombinant human bone morphogenetic protein 2 in a standardized rabbit sinus model: a radiographic and histologic analysis. Clinical Oral Implants Research. ,vol. 23, pp. 682- 689 ,(2012) , 10.1111/J.1600-0501.2011.02222.X
A W Yasko, J M Lane, E J Fellinger, V Rosen, J M Wozney, E A Wang, The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. Journal of Bone and Joint Surgery, American Volume. ,vol. 74, pp. 659- 670 ,(1992) , 10.2106/00004623-199274050-00005
Oliver Hanisch, Michael D Rohrer, Dimitris N. Tatakis, Peter S. Wöhrle, Ulf M.E. Wikesjö, John M. Wozney, Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates. International Journal of Oral & Maxillofacial Implants. ,vol. 12, pp. 785- 792 ,(1997)