Tumor-specific genetic aberrations in cell-free DNA of gastroesophageal cancer patients

摘要: The applicability of liquid biopsies is studied intensively in all types cancer and analysis circulating tumor DNA (ctDNA) has recently been implemented clinically for mutation detection lung cancer. ctDNA may provide information about quantity mutations present the tumor, as such have many potential applications diagnosis treatment It suggested that overcome issue intra-tumor heterogeneity faced by tissue serve an additional diagnostic tool. Furthermore, are potentially helpful monitoring response well minimal residual disease relapse. Gastroesophageal cancers (GEC) high mortality rates majority patients with advanced stage at or succumb due to recurrence even after radical resection primary tumor. Biomarkers can help optimize strategy thus highly desirable. study a review published data on GEC patients. We identified 25 studies which tumor-specific genetic aberrations were investigated plasma serum discuss these relation methods applied analysis. used greatly influence sensitivity and, therefore, clinical applications. found GEC, although limited number, promising several profiling tumors progression. However, more needed establish if how this be implemented.