Gallic acid intake induces alterations to systems metabolism in rats.
作者： Xiaohuo Shi , Chaoni Xiao , Yulan Wang , Huiru Tang
DOI: 10.1021/PR301041K
关键词: Pharmacology 、 Glycolysis 、 Metabolism 、 Biochemistry 、 Metabolome 、 Gallic acid 、 Amino acid 、 Glycogenolysis 、 Oxidative stress 、 Citric acid cycle 、 Biology
摘要: Gallic acid (GA) and its metabolites are polyphenolic compounds present in daily diets herbal medicines. To understand the GA effects on endogenous metabolism of mammals, we systematically analyzed metabonomic responses rat plasma, liver, urine, feces to a single dosage 120 600 mg/kg, which were below no-obvious-adverse-effect-level 1 g/kg for rats. Clinical chemistry histopathological assessments conducted provide complementary information. Our results showed that intake induced significant changes multiple biological matrices. Such more outstanding liver than other matrices clearly dose- time-dependence. The suggested GA-induced promotion oxidative stress as major effect. High-dose caused metabolic involving glycogenolysis, glycolysis, TCA cycle, amino acids, purines, pyrimidines, together with gut microbiota functions. Low-dose only c...
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