Vascular endothelial growth factor A is a putative paracrine regulator in seasonally controlled spermatogenesis: Insights from a ruminant model, the roe deer
作者： Jennifer Schön , Steffen Blottner , Christoph Gabler , Jörns Fickel
DOI: 10.3109/08977191003587668
关键词: Vascular endothelial growth factor 、 Vascular endothelial growth factor A 、 Spermatogenesis 、 Spermiogenesis 、 Endocrinology 、 Paracrine signalling 、 Cell biology 、 Receptor 、 Internal medicine 、 Sertoli cell 、 Biology 、 Vascular permeability
摘要: Vascular endothelial growth factor A (VEGFA) influences spermatogenesis, but its impact on seasonally regulated sperm production is still not fully understood. Thus, we investigated both expression levels and localisation of VEGFA receptors VEGFR1 2 in roe buck testis via real-time reverse transcription polymerase chain reaction immunohistochemistry relation to seasonal changes the cellular composition testis. was expressed by interstitial cells while were found perivascular cells. Inside tubules, located spermatogonia spermatocytes, present elongating spermatids VEGFR2 Sertoli mRNA tenfold lower than VEGF mRNAs. Relative (divided number expressing cells) showed an increase towards rut (July/August) a decrease thereafter. The results suggest involvement adjustment vascular permeability as well spermiogenesis proliferation spermatogonia.
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