Training increases peroxiredoxin 2 contents in the erythrocytes of overweight/obese men suffering from type 2 diabetes
作者： David Assadi Moghaddam , Anke Heber , Dario Capin , Thorsten Kreutz , David Opitz
DOI: 10.1007/S10354-011-0037-0
关键词: Diabetes mellitus 、 Peroxiredoxin 2 、 Peroxiredoxin 、 Overweight 、 Endurance training 、 Type 2 Diabetes Mellitus 、 Type 2 diabetes 、 Endocrinology 、 Obesity 、 Internal medicine 、 Medicine
摘要: Type 2 diabetes mellitus (T2DM) is associated with an increased release of free radicals which play important role in the manifestation and progression diabetic complications. Peroxiredoxins are thought to be essential components erythrocyte antioxidative defense. Therefore, we compared peroxiredoxin isoform contents (PRDX1-6 immuno-histochemial stainings) erythrocytes overweight/obese T2DM men (n = 6) BMI-matched non-diabetic male control subjects 6). Only PRDX1 PRDX2 proteins were detectable using immunohistochemical methods. was significantly relative (+95.9%, P ≤ 0.05). Furthermore, studied influence a 3-month endurance training program (3 times week, cycling at 75% maximal heart rate) on 11). Training rest (+96%, The up-regulation system may help counteract patients.
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