Statistical models for estimating the genetic basis of repeated measures and other function-valued traits.

作者: Scott D. Pletcher , Florence Jaffrézic

DOI: 10.1093/GENETICS/156.2.913

关键词: BiologyGenetic correlationContrast (statistics)RegressionCharacter (mathematics)Range (statistics)Statistical modelFunction (mathematics)StatisticsGeneticsCovariance

摘要: The genetic analysis of characters that are best considered as functions some independent and continuous variable, such age, can be a complicated matter, simple efficient procedure is desirable. Three methods common in the literature: random regression, orthogonal polynomial approximation, character process models. goals this article (i) to clarify relationships between these methods; (ii) develop general extension model relaxes correlation stationarity, its most stringent assumption; (iii) compare contrast techniques evaluate their performance across range actual simulated data. We find model, described 1999 by Pletcher Geyer, successful method for data examined study. It provides reasonable description wide different covariance structures, it results models Our suggests variance Drosophila mortality declines with while constant at all ages reproductive output. For growth beef cattle, however, increases linearly from birth, correlations high observed ages.

参考文章(18)
J Jamrozik, L R Schaeffer, Z Liu, G Jansen, Multiple trait random regression test day model for production traits Interbull Bulletin. pp. 43- ,(1997)
Bruce Walsh, Michael Lynch, Genetics and Analysis of Quantitative Traits ,(1996)
Charles J. Geyer, Scott D. Pletcher, The genetic analysis of age-dependent traits: modeling the character process. Genetics. ,vol. 153, pp. 825- 835 ,(1999) , 10.1093/GENETICS/153.2.825
David Lofsvold, Mark Kirkpatrick, Michael Bulmer, Analysis of the inheritance, selection and evolution of growth trajectories. Genetics. ,vol. 124, pp. 979- 993 ,(1990) , 10.1093/GENETICS/124.4.979
J. Jamrozik, L.R. Schaeffer, J.C.M. Dekkers, Genetic Evaluation of Dairy Cattle Using Test Day Yields and Random Regression Model Journal of Dairy Science. ,vol. 80, pp. 1217- 1226 ,(1997) , 10.3168/JDS.S0022-0302(97)76050-8
Mark Kirkpatrick, Nancy Heckman, A quantitative genetic model for growth, shape, reaction norms, and other infinite-dimensional characters Journal of Mathematical Biology. ,vol. 27, pp. 429- 450 ,(1989) , 10.1007/BF00290638
Mark Kirkpatrick, David Lofsvold, MEASURING SELECTION AND CONSTRAINT IN THE EVOLUTION OF GROWTH. Evolution. ,vol. 46, pp. 954- 971 ,(1992) , 10.1111/J.1558-5646.1992.TB00612.X
Mary J. Lindstrom, Douglas M. Bates, Nonlinear Mixed Effects Models for Repeated Measures Data Biometrics. ,vol. 46, pp. 673- 687 ,(1990) , 10.2307/2532087
Edward F. Vonesh, Vernon M. Chinchilli, Kewei Pu, Goodness-of-fit in generalized nonlinear mixed-effects models. Biometrics. ,vol. 52, pp. 572- 587 ,(1996) , 10.2307/2532896