The predictive value of the preoperative C-reactive protein-albumin ratio for early recurrence and chemotherapy benefit in patients with gastric cancer after radical gastrectomy: using randomized phase III trial data.

摘要: The definition and predictors of early recurrence (ER) for gastric cancer (GC) patients after radical gastrectomy are unclear. A minimum-p value approach was used to evaluate the optimal cutoff recurrence-free survival determine ER late (LR). Receiver operating characteristic curves were generated inflammatory indices. Potential risk factors assessed with a Cox regression model. decision curve analysis performed clinical utility. total 401 recruited in trial (NCT02327481) from January 2015 April 2016 included this study. length distinguish between (n = 44) LR (n = 52) 12 months. Factors associated preoperative C-reactive protein–albumin ratio (CAR) ≥ 0.131, stage III postoperative adjuvant chemotherapy (PAC) > 3 cycles. model consisting both CAR TNM had higher predictive ability better utility than alone. Further stratification found that CAR   3 cycles (p  (54.2% vs 16.0%, p = 0.004), rather 1–3 (58.3% 54.2%, p = 0.824). interval months be threshold differentiating LR. Preoperative promising predictor PAC response. may not exert protective effect against GC CAR ≥ 0.131.