PARPs and ADP-Ribosylation: 50 Years … and Counting
作者： W. Lee Kraus
DOI: 10.1016/J.MOLCEL.2015.06.006
关键词: Protein processing 、 Poly ADP ribose polymerase 、 Genetics 、 Rna processing 、 Chromatin 、 DNA damage 、 Computational biology 、 NAD metabolism 、 Poly Adenosine Diphosphate Ribose 、 ADP-ribosylation 、 Biology
摘要: Over 50 years ago, the discovery of poly(ADP-ribose) (PAR) set a new field science in motion—the poly(ADP-ribosyl) transferases (PARPs) and ADP-ribosylation. The is still flourishing today. diversity biological processes now known to require PARPs ADP-ribosylation was practically unimaginable even two decades ago. From an initial focus on DNA damage detection repair response genotoxic stresses, has expanded include regulation chromatin structure, gene expression, RNA processing wide range systems, including reproduction, development, aging, stem cells, inflammation, metabolism, cancer. This special issue Molecular Cell includes collection three Reviews, Perspectives, SnapShot, which together summarize current state suggest where it may be headed.
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