Changes in cyclic 3'5'-adenosine monophosphate tissue concentration and net fluid transport in the cat's small intestine elicited by cholera toxin, arachidonic acid, vasoactive intestinal polypeptide and 5-hydroxytryptamine.
作者： S. EKLUND , I. BRUNSSON , M. JODAL , O. LUNDGREN
DOI: 10.1111/J.1748-1716.1987.TB08046.X
关键词: Small intestine 、 Endocrinology 、 Cholera toxin 、 Intestinal absorption 、 Secretion 、 Vasoactive intestinal peptide 、 Fluid transport 、 Biology 、 Internal medicine 、 Adenosine monophosphate 、 Intestinal mucosa
摘要: We have analysed tissue cyclic 3'5'-adenosine monophosphate (cAMP) concentration in different fractions of the cat's small intestinal mucosa during secretion elicited vivo by four secretagogues: cholera toxin (administered intraluminally), vasoactive polypeptide (VIP; given i.a.), arachidonic acid (AA; administered intraluminally) and 5-hydroxytryptamine (5-HT; i.a.). Cholera was found to increase cAMP villi but not crypts. The VIP, AA 5-HT did influence despite a profuse net fluid secretion. Hexamethonium inhibited significantly concentration. There is strong evidence for view that villus crypt regions functions, taking place crypts absorption villi. However, lack reported this study suggests model does reach results are agreement with role mediating from crypts, compatible inhibiting It suggested observed toxin, major part mediated intramural enteric reflexes.
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