Antimicrobial and toxicological activities of five medicinal plant species from Cameroon Traditional Medicine

摘要: Infectious diseases caused by multiresistant microbial strains are on the increase. Fighting these with natural products may be more efficacious. The aim of this study was to investigate in vitro antimicrobial activity methanolic, ethylacetate (EtOAc) and hexanic fractions five Cameroonian medicinal plants (Piptadeniastum africana, Cissus aralioides, Hileria latifolia, Phyllanthus muellerianus Gladiolus gregasius) against 10 pathogenic microorganisms urogenital gastrointestinal tracts. were screened for their chemical composition vivo acute toxicity carried out most active extracts order assess inhibitory selectivity. agar well-diffusion micro dilution methods used determination inhibition diameters (ID) Minimum concentrations (MIC) respectively 8 bacterial species including two Gram positive (Staphylococcus aureus, Enterococcus faecalis), six negative (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Shigella flexneri, Salmonella typhi) fungal isolates (Candida albicans, Candida krusei). done according Harbone (1976), evaluation WHO protocol hepatic as well serum parameters measured liver kidney functions. components each plant's extract varied solvent used, they found contain alkaloids, flavonoids, polyphenols, triterpens, sterols, tannins, coumarins, glycosides, cardiac glycosides reducing sugars. methanolic Piptadeniastum africana presented highest activities all tested ID varying from 26 mm MIC 2.5 0.31 mg/ml. Piptadeniastrum indicated that not toxic. At dose 4 g/kg body weight, function tests induced no adverse effect organs. These results showed that, can phytomedicines which therapeutically infections agents. muellerianus, antimicrobial, toxicity, tests, Cameroon Traditional Medicine