CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia
作者： Jeevisha Bajaj , Takaaki Konuma , Nikki K. Lytle , Hyog Young Kwon , Jailal N. Ablack
DOI: 10.1016/J.CCELL.2016.10.003
关键词: Cancer stem cell 、 Cancer 、 Leukemia 、 Medicine 、 Immunology 、 Myelogenous 、 Stem cell 、 Integrin binding 、 Therapeutic approach 、 CD98
摘要: Acute myelogenous leukemia (AML) is an aggressive disease associated with drug resistance and relapse. To improve therapeutic strategies, it critical to better understand the mechanisms that underlie AML progression. Here we show integrin binding glycoprotein CD98 plays a central role in AML. promotes propagation lethality by driving engagement of cells their microenvironment maintaining leukemic stem cells. Further, delivery humanized anti-CD98 antibody blocks growth patient-derived AML, highlighting importance this pathway human disease. These findings indicate microenvironmental interactions are key regulators disrupting these signals targeted inhibitors such as antibodies may be valuable approach for adults children
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