Selective functionalization of methylene bridges of calix[6]arenes. Isolation and identification of stable conformers of methyl ether of p-tert-butylcalix[6]arene.
作者： Shafali Arora , Shivali Sharma , Venus S Mithu , Chang Hee-Lee , Kamaljit Singh
DOI: 10.1039/C4CC10400E
关键词: Medicinal chemistry 、 Single crystal 、 Structure analysis 、 Conformational isomerism 、 Column chromatography 、 Surface modification 、 Ether 、 Stereochemistry 、 Methylene 、 Chemistry
摘要: Direct disubstitution at the methylene bridges of p-tert-butylcalix[6]arenemethyl ether has been achieved for first time using a lithiation–substitution protocol. Two stable conformers have isolated column chromatography, and their structures unambiguously confirmed from 1D, 2D variable temperature NMR studies single crystal X-ray structure analysis.
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