Synthesis, characterization, biological evaluation and molecular docking of a new quinazolinone-based derivative as a potent dual inhibitor for VEGFR-2 and EGFR tyrosine kinases.
作者： Yassine Riadi , El Hassane Anouar , Alhumaidi B. Alabbas , Mohammed H. Geesi , Ali Altharawi
DOI: 10.1080/07391102.2021.1890221
关键词: Derivative (chemistry) 、 Thio- 、 VEGF receptors 、 Quinazolinone 、 Stereochemistry 、 Docking (molecular) 、 Tyrosine kinase 、 Biological evaluation 、 Chemistry 、 Dual inhibitor
摘要: An efficient process for the preparation of a new ethyl 2-((3-(4-fluorophenyl)-6-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)thio) acetate (5) was described. The prepared derivative synthesized usi...
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