Human interstitial cellular model in therapeutics of heart valve calcification.
作者： Caimei He , Hai Tang , Zijian Mei , Nichujie Li , Zhi Zeng
DOI: 10.1007/S00726-017-2432-3
关键词: Drug discovery 、 Valve replacement 、 Aortic valve 、 Fibrosis 、 Bioinformatics 、 Osteoprotegerin 、 Pathology 、 Inflammation 、 Calcification 、 Aortic valve stenosis 、 Medicine
摘要: Calcific aortic valve disease is a common, severe heart condition that currently with no proven, effective drug treatment and requires surgical replacement or an entire explanation. Thus, developing novel, targeted therapeutic approaches becomes major goal for cardiovascular research. To achieve this goal, isolated interstitial cells could be advanced model to explore molecular mechanisms measure efficacy. Based on progress, harbor components of inflammation fibrosis coupled with proteins, example, BMP-2, TLRs, RANKL, Osteoprotegerin, have been proposed. Small molecules antibodies targeting these proteins shown promising efficacy either reversing slowing down calcification development in vitro. In review, we summarize potential therapeutics some highlights of cellular models.
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