Phosphorescent Iridium(III) Complexes for Bioimaging

摘要: Phosphorescent iridium(III) complexes have received increasing attention in bioimaging applications owing to their advantageous photophysical properties and efficient internalization into live cells. In this chapter, we summarize the recent design of reagents based on phosphorescent complexes. The utilizations cationic, neutral, zwitterionic been described first. Complexes showing aggregation-induced phosphorescence also included considering absence commonly observed aggregation-caused quenching. Then discuss functionalization with biological substrates reactive groups, which allows non-covalent covalent interaction, respectively, intracellular biomolecules. As are very sensitive toward surrounding ligands microenvironment, use these as sensors for gas molecules, ions, amino acids has summarized. Additionally, incorporation dendrimer, polymer, nanoparticle systems providing attractive functionalities discussed. Furthermore, various strategies, including near-infrared-emitting two-photon excitable complexes, upconversion nanoparticles, lifetime-based microscopy techniques, enhance signal-to-noise ratios At last, multi-mode imaging techniques involving magnetic resonance described.