Crucial Roles of TNFAIP8 Protein in Regulating Apoptosis and Listeria Infection
作者： Thomas P. Porturas , Honghong Sun , George Buchlis , Yunwei Lou , Xiaohong Liang
关键词: Listeria monocytogenes 、 Spleen 、 Gene knockdown 、 Apoptosis 、 Tumor necrosis factor alpha 、 Pathogen 、 RAC1 、 Listeria infection 、 Biology 、 Cell biology
摘要: TNF-α-induced protein 8 (TNFAIP8 or TIPE) is a newly described regulator of cancer and infection. However, its precise roles mechanisms actions are not well understood. We report in this article that TNFAIP8 regulates Listeria monocytogenes infection by controlling pathogen invasion host cell apoptosis RAC1 GTPase-dependent manner. TNFAIP8-knockout mice were resistant to lethal L. had reduced bacterial load the liver spleen. knockdown murine HEPA1-6 cells increased apoptosis, into cells, resulted dysregulated activation. could translocate plasma membrane preferentially associate with activated RAC1-GTP. The combined effect sensitivity clearance likely protected from listeriosis. Thus, death infected through RAC1, pathogenesis
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