New Targets for Schizophrenia Treatment beyond the Dopamine Hypothesis.

摘要: Schizophrenia has been primarily associated with dopamine dysfunction, and treatments have developed that target the pathway in central nervous system. However, accumulating evidence shown core pathophysiology of schizophrenia might involve dysfunction dopaminergic, glutamatergic, serotonergic, gamma-aminobutyric acid (GABA) signaling, which may lead to aberrant functioning interneurons manifest as cognitive, behavioral, social through altered a broad range macro- microcircuits. The interactions between neurotransmitters can be modeled nodes edges by using graph theory, oxidative balance, immune, glutamatergic systems represent multiple interlocking at hub; imbalance within any these affect entire Therefore, this review attempts address novel treatment targets beyond hypothesis, including glutamate, serotonin, acetylcholine, GABA, inflammatory cytokines. Furthermore, we outline possibly integrated strategies aimed different symptoms or phases illness. We anticipate reversing anomalous activity combinations beneficial schizophrenia.