Low HDL cholesterol, aggression and altered central serotonergic activity.

摘要: Many studies support a significant relation between low cholesterol levels and poor impulse, aggression mood control. Evidence exists also for causal link brain serotonin (5-HT) activity these behaviors. Mechanisms linking hostile or self-destructive behavior are unknown, but it has been suggested that influences 5-HT function. This study was designed to explore the relationship plasma cholesterol, measures of impulsivity aggression, indices function in personality disordered cocaine addicts. Thirty-eight hospitalized male patients (age 36.8±7.1) were assessed with DSM-III-R, Buss–Durkee Hostility Inventory (BDHI), Barratt Impulsiveness Scale (BIS) Brown–Goodwin Assessment Life History Aggression. Fasting basal (total, LDL HDL) determined 2 weeks after discontinuation. On same day by neuroendocrine (cortisol prolactin) psychological (NIMH ‘high’ self-rating scales) responses following meta-chlorophenylpiperazine (m-CPP) challenges. Reduced responses, feelings increased ‘activation-euphoria’ m-CPP have interpreted as indicating alterations variety psychiatric conditions. Significantly lower HDL found who had history (P=0.005). Lower be significantly associated more intense well blunted cortisol (P=0.033, P=0.025 P=0.018, respectively). gives further existing evidence some individuals, probability exhibiting impulsive violent behaviors may when is low. It suggests causally related.