The digestive system manifestations of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy): review of 11 cases.

摘要: Rosai-Dorfman disease (RDD), originally described as sinus histiocytosis with massive lymphadenopathy, is a rare histiocytic proliferative disorder distinctive microscopic appearance. Formerly thought to be process limited lymph nodes, involvement by RDD has now been documented in many organ systems, notably bone, skin and soft tissue, central nervous system, eye orbit, upper respiratory tract. The digestive however, affected only exceptionally, reflected the existence of handful individual case reports. In this article, we report 11 patients which involved intestinal tract, liver, or pancreas, describe most salient clinicopathologic features. specific site within system was gastrointestinal tract 5, liver pancreas 1. Most also had evidence other extranodal sites, well 1 more node groups.