Oxygen Supply Dependency in the Critically Ill — A Continuing Conundrum

摘要: Although they were not the first to observe it, a seminal paper by Danek et al. (1980) ushered in decade of concern for oxygen supply dependency critically ill patients. That continues today with some urgency because uncertainty what it means. The observation made was that O2 uptake (VO2) varied directly delivery (DO2) even at very high rates patients adult respiratory distress syndrome (ARDS). A similar linear relationship between VO2 and DO2 seen another group ventilator who had been diagnosed ARDS. In this earlier studies, appeared demand higher than expected satisfied ARDS if raised well above normal resting levels. authors suggested due possible disturbance regulatory control blood flow periphery as disruption cellular structure mitochondrial dysfunction.