Hematological effects of exposure to mixtures of selected ethylene glycol alkyl ethers in rats

摘要: Exposure to various ethylene glycol monoalkyl ethers (EGAEs) is known result in hemolytic effect caused by their metabolites, appropriate alkoxyacetic acids, generated via both alcohol dehydrogenase and aldehyde dehydrogenase. It has been shown many studies that administration of single doses EGAEs rats lead dose- time-dependent anemia. The repeated exposure isopropoxyethanol (IPE), butoxyethanol (BE), contrary methoxyethanol (ME) ethoxyethanol (EE), resulted significantly less pronounced hematological changes. While the majority effects were dramatic at beginning exposure, later these changes clearly regressed despite continued weekly ethers. gradual recovery from anemia may be associated with tolerance development IPE BE. ME demonstrated high hematotoxicity, which increased progressively reached a maximum end 4 week whereas EE revealed moderate effects. might suspected modified activity simultaneously treated compounds. In co-exposed subcutaneously relatively low 0.75 mM + for weeks, comparison animals (0.75 mM) alone observed. At period, i.e., weeks alterations same markedly elevated time, except mean corpuscular volume (MCV) values, lower group. higher dose 1.25 mM/kg did not modify hematotoxicity (at its harmful treatment. amelioration parameters inhibitory on metabolism. On contrary, an accumulation methoxyacetic acid ethoxyacetic acid, toxic metabolites EE, respectively, no two chemicals responsible exposure.