Glucocorticoid receptor is involved in the breed-dependent transcriptional regulation of 3β-hydroxysteroid dehydrogenase in the liver of preweaning piglets
作者： Xian Li , Yimin Jia , Runsheng Li , Zhiyuan Sun , Xi Li
DOI: 10.1186/S12917-015-0441-6
关键词: Hormone 、 Breed 、 Blood serum 、 Regulation of gene expression 、 Internal medicine 、 Glucocorticoid receptor 、 Endocrinology 、 Biology 、 Transcriptional regulation 、 Purebred 、 Catabolism
摘要: Background Hepatic 3β-hydroxysteroid dehydrogenase (3β-HSD) plays an important role in steroid inactivation and catabolism. Serum concentrations of hormones differ significantly between breeds pigs, however the molecular mechanism regulating hepatic 3β-HSD expression different pigs is poorly understood. In present study, we used preweaning purebred male Large White (LW) Erhualian (EHL) piglets as model to investigate breed difference regulation gene porcine liver.
biomedcentral.com
springer.com
cabdirect.org
paperity.org
core.ac.uk 参考文章(46)
Steven R King, Holly A LaVoie, Gonadal transactivation of STARD1, CYP11A1 and HSD3B. Frontiers in Bioscience. ,vol. 17, pp. 824- 846 ,(2012) , 10.2741/3959
Suzanne M. Clavey, John R. D. Stalvey, Evidence that Testosterone Regulates Leydig Cell 3β‐Hydroxysteroid Dehydrogenase‐Isomerase Activity by a Trans‐Acting Factor Distal to the Androgen Receptor Journal of Andrology. ,vol. 13, pp. 93- 99 ,(1992) , 10.1002/J.1939-4640.1992.TB01635.X
Fraser M. Rogerson, Jean-Guy LeHoux, J.Ian Mason, Expression and characterization of isoforms of 3β-hydroxysteroid in the hamster The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 55, pp. 481- 487 ,(1995) , 10.1016/0960-0760(95)00197-2
Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman, Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biology. ,vol. 3, pp. 1- 12 ,(2002) , 10.1186/GB-2002-3-7-RESEARCH0034
Qinqin Zha, Yan Wang, Yan Fan, Meng-Yang Zhu, Dexamethasone-induced up-regulation of the human norepinephrine transporter involves the glucocorticoid receptor and increased binding of C/EBP-β to the proximal promoter of norepinephrine transporter. Journal of Neurochemistry. ,vol. 119, pp. 654- 663 ,(2011) , 10.1111/J.1471-4159.2011.07448.X
Y Nishio, H Isshiki, T Kishimoto, S Akira, A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction. Molecular and Cellular Biology. ,vol. 13, pp. 1854- 1862 ,(1993) , 10.1128/MCB.13.3.1854
Céline Désautés, Alain Sarrieau, Jean-Claude Caritez, Pierre Mormède, Behavior and pituitary-adrenal function in large white and Meishan pigs Domestic Animal Endocrinology. ,vol. 16, pp. 193- 205 ,(1999) , 10.1016/S0739-7240(99)00014-4
Zhiyuan Sun, Maojun Liu, Huafeng Zou, Xian Li, Guoqing Shao, Ruqian Zhao, None, Vaccination inhibits TLR2 transcription via suppression of GR nuclear translocation and binding to TLR2 promoter in porcine lung infected with Mycoplasma hyopneumoniae. Veterinary Microbiology. ,vol. 167, pp. 425- 433 ,(2013) , 10.1016/J.VETMIC.2013.08.022
Jaime E. Perry, John R. D. Stalvey, Gonadal steroids modulate adrenal fasciculata 3 beta-hydroxysteroid dehydrogenase-isomerase activity in mice. Biology of Reproduction. ,vol. 46, pp. 73- 82 ,(1992) , 10.1095/BIOLREPROD46.1.73
Martin Krøyer Rasmussen, Bo Ekstrand, Regulation of 3β-hydroxysteroid dehydrogenase and sulphotransferase 2A1 gene expression in primary porcine hepatocytes by selected sex-steroids and plant secondary metabolites from chicory (Cichorium intybus L.) and wormwood (Artemisia sp.) Gene. ,vol. 536, pp. 53- 58 ,(2014) , 10.1016/J.GENE.2013.11.092