Innate Signatures of Immune Mediated Resolution and Persistence of Hepatitis C Virus Infections
作者： Robert E. Lanford
DOI: 10.1007/978-1-4419-7219-4_9
关键词: Hepatitis C virus 、 Acquired immune system 、 Interferon-stimulated gene 、 Innate immune system 、 Interferon 、 Medicine 、 Virology 、 Virus 、 Immune system 、 Immunology 、 Chronic infection
摘要: Hepatitis C Virus infections have a high propensity to induce lifelong persistent infections. A number of host and environmental variables been shown impact the rate infection outcome interferon (IFN)-based therapies. This review briefly highlights few relevant observations that made with regard viral clearance. HCV induces highly elevated stimulated gene (ISG) response in liver during both acute chronic The role this containing spread virus mounting an effective adaptive immune is poorly understood. fact hepatic ISG negatively correlates IFN therapy counter-intuitive remains be explained satisfactorily. failure T cell clear appears reside deficiency CD4 help leading anergic CD8 cells, which may also related whether innate properly orchestrates early infection. importance illustrated by recent genome wide association studies revealing remarkable correlation between genetic polymorphisms IL28B (IFNλ3) clearance infected cells or therapy, yet mechanisms IFNλ3 other effectors influence are currently
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