Neurobiological Elements of Cognitive Dysfunction in Down Syndrome: Exploring the Role of APP
作者： Martha Millan Sanchez , Sietske N. Heyn , Devsmita Das , Sarah Moghadam , Kara J. Martin
DOI: 10.1016/J.BIOPSYCH.2011.08.016
关键词: Neuroscience 、 Down syndrome 、 Hippocampus 、 Locus coeruleus 、 Hippocampal formation 、 Degeneration (medical) 、 Amyloid precursor protein 、 Cholinergic 、 Psychology 、 Neurodegeneration
摘要: Down syndrome (DS) is the most common cause of cognitive dysfunction in children. Additionally, adults with DS will eventually show both clinical and neuropathologic hallmarks Alzheimer's disease (AD). The hippocampal formation constitutes primary target for degeneration AD DS. Over past few years, we have studied molecular mechanisms behind this region its major inputs mouse models Our investigation has suggested that loss inputs, particularly cholinergic noradrenergic terminals, leads to de-afferentation Ts65Dn model Interestingly, were able link overexpression amyloid precursor protein (App) gene neurons models. We examined underlying multiple systems extensive projections hippocampus role App neurodegeneration. Understanding helped us test several therapeutic strategies successfully Here review these discuss ways translate our findings into possible interventions humans.
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