CRTH2 Plays an Essential Role in the Pathophysiology of Cry j 1-Induced Pollinosis in Mice

摘要: PGD(2) is the major prostanoid produced during acute phase of allergic reactions. Two receptors have been isolated, DP and CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), but whether they participate in pathophysiology diseases remains unclear. We investigated role initiation rhinitis mice. First, we developed a novel murine model pollinosis, type seasonal rhinitis. Additionally, pathophysiological differences pollinosis were compared between wild-type gene-deficient An effect treatment with ramatroban, CRTH2/T-prostanoid receptor dual antagonist, was also determined. Repeated intranasal sensitization Cry j 1, allergen Cryptomeria japonica pollen, absence adjuvants significantly exacerbated nasal hyperresponsive symptoms, 1-specific IgE IgG1 production, eosinophilia, 1-induced vitro production IL-4 IL-5 by submandibular lymph node cells. mRNA mucosa elevated 1-sensitized Following repeated mice had weaker IgE/IgG1 cells than did Similar results found treated ramatroban. These suggest that PGD(2)-CRTH2 interaction following plays proinflammatory rhinitis, especially