Effects of fluoride-ion-implanted titanium surface on the cytocompatibility in vitro and osseointegatation in vivo for dental implant applications.

摘要: As an attractive technique for the improvement of biomaterials, Plasma immersion ion implantation (PIII) has been applied to modifying titanium material dental implant application. The present study investigated cytocompatibility and early osseointegration fluoride-ion-implanted (F-Ti) surface implants, both characterizing in their composition oxide fluoride. F-Ti was evaluated vitro by using scanning electron microscope, Cell Counting Kit-8 assay, alkaline phosphatase activity quantitative real-time polymerase chain reaction. results showed that weakened effects Porphyromonas gingivalis exerted on MG-63 cells terms morphology, proliferation, differentiation, genetic expression when were co-cultured F-Ti. Meanwhile, osteogenic implants assessed vivo via evaluating histological morphology estimating histomorphometric parameters. analysis toluidine blue staining indicated new bone more mature subjects with group, which exhibited Haversian system, mean bone-implant contact value group slightly higher than cp-Ti (p>0.05). Fluorescence bands wider brighter intensity fluorochromes deposited at sites mineralized formation significantly surfaces surfaces, within 2nd, 3rd 4th weeks (p<0.05). An indication is fluoride modified can promote osseointegration, thus providing a promising alternative clinical use.