Interaction between Social/Psychosocial Factors and Genetic Variants on Body Mass Index: A Gene-Environment Interaction Analysis in a Longitudinal Setting.

摘要: Obesity, which develops over time, is one of the leading causes chronic diseases such as cardiovascular disease. However, hundreds BMI (body mass index)-associated genetic loci identified through large-scale genome-wide association studies (GWAS) only explain about 2.7% variation. Most common human traits are believed to be influenced by both and environmental factors. Past suggest a variety features that associated with obesity, including socioeconomic status psychosocial This study combines gene/regions factors explore whether social/psychosocial (childhood adult status, social support, anger, burden, stressful life events, depressive symptoms) modify effect sets variants on in European American African participants Health Retirement Study (HRS). In order incorporate longitudinal phenotype data collected HRS investigate entire single nucleotide polymorphisms (SNPs) within gene/region simultaneously, we applied novel set-based test for gene-environment interaction (LGEWIS). Childhood (parental education) was found around SNP rs9540493 Americans HRS. The most significant (rs9540488) childhood suggestively replicated Multi-Ethnic Atherosclerosis (MESA) (p = 0.07).