Possible role of placental leptin in pregnancy: a review.

摘要: Leptin was initially identified as an adipocyte-derived hormone that decreases food intake and body weight via its receptor in the hypothalamus. Subsequent animal studies revealed various physiologic functions of leptin. plays essential role reproduction by regulating gonadotropin-releasing secretion from It also modulates glucose metabolism increasing insulin sensitivity activates sympathetic nervous system. In humans, leptin is produced placental trophoblasts secreted into both maternal fetal circulation. production placenta increased pregnancies complicated with several pathologic conditions. gene expression augmented severe preeclampsia, plasma levels preeclampsia are significantly higher than those normotensive pregnant women. diabetic pregnancy treatment. Furthermore, proposed to play a functional implantation virtue stimulatory effect on matrix metalloproteinase cytotrophoblast. Dysregulation and/or function may be implicated pathogenesis disorders during pregnancy, such recurrent miscarriage, gestational diabetes, intrauterine growth retardation, preeclampsia. this review, possible roles discussed.