Bioadhesive microspheres. I: A novel electrobalance-based method to study adhesive interactions between individual microspheres and intestinal mucosa

摘要: Abstract A simple electrobalance-based method has been developed to measure bioadhesive interactions between individual polymer microspheres and biological tissues. Environmental conditions, such as temperature pH, are easily controlled mimic physiological parameters. The technique is unique in that it allows the measurement of many parameters: compressive deformation, peak load, yield point, tensile deformation fracture strength, failure, work, returned work a single experiment. shown be statistically reproducible accurate. Using this technique, several hydrophobic, thermoplastic polymers one hydrogel were studied. Co-polymers fumaric sebacic acid, polyanhydride family, produced strengths greater than 50 mN/cm 2 with rat small intestinal mucosa, vitro. We suggest bioadhesion these hard, bioerodible materials not due chain entanglement, required by diffusion theory bioadhesion, but numerous hydrogen bonds generated hydrophilic functional groups (-COOH) mucus glycoproteins.