Extrasynaptic distribution of monoamine transporters and receptors.

摘要: Publisher Summary Extra-synaptic, as well synaptic sites for monoaminergic transmission have been elucidated by using electron microscopic immunocytochemistry the localization of sequence specific antipeptide antisera against recently cloned vesicular and plasmalemmal monoamine transporters receptors. The ultrastructural evidence extrasynaptic is described in this chapter, focusing primarily on research conducted striatum: caudate-putamen nucleus (CPN) core or shell accumbens (NAc). These striatal compartments show regional differences extracellular concentrations that are attributed, part, to transporter availability. availability monoamines markedly influences expression distribution receptors controlling motor limbic functions. result study supports idea central neurons can release a paracrine manner affect diverse targets. While axon terminals sometimes form recognizable synapses, subcellular distributions suggest reuptake occurs largely outside cleft thus facilitating activation distant This conclusion consistent with subtype selective dopamine serotonin non-synaptic plasma membranes dendrites.