Excitotoxin paraventricular nucleus lesions: stress and endocrine reactivity and oxytocin mRNA levels.
作者： Michael F. Callahan , Clara R. Thore , David K. Sundberg , Kenneth A. Gruber , Keith O'Steen
DOI: 10.1016/0006-8993(92)91499-5
关键词: Hypothalamus 、 Hypertonic saline 、 Parvocellular cell 、 Neuropeptide 、 Biology 、 Internal medicine 、 Oxytocin 、 Endocrinology 、 Vasopressin 、 Lesion 、 Ibotenic acid
摘要: Electrolytic lesion of the paraventricular nucleus (PVN) hypothalamus blocks tachycardia response to stress. The current study examined effects chemical PVN parvocellular neurons on cardiovascular and endocrine responses stress content hypothalamic oxytocin (OT) mRNA levels. Acute footshock increased heart rate in both ibotenic acid control groups animals; however, was significantly lower animals with a than controls. Lesion also attenuated increase plasma OT induced by stress, 4-fold group versus 20-fold for There not generalized decrease hormonal responsiveness since an osmotic challenge exaggerated group. no difference between arterial pressure vasopressin acute Neurotoxin lesions resulted significant depletions VP all levels spinal cord decreased dorsal brainstem. Ibotenic changes PVN, SON PP. In addition, 48-h dehydration PVN. These data indicate that play role integration stressful stimuli provide further evidence project brainstem cord.
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