Pathology and Pathophysiology of Proteinuric Glomerular Disease

摘要: Renal glomerular diseases began to be reasonably understood during the first part of this century when major emphasis for classification shifted from pure clinical grounds clinicopathological correlations. The popularization renal biopsies, refinements laboratory methods detection possible etiological factors, availability electron microscopy, development experimental models, and wealth immunologic information accumulated last two or three decades all have contributed greatly advance our knowledge; yet as now there is not one generally accepted diseases. reason multifactorial. glomerulus has very limited ways reacting injury; therefore, different insults might express indistinguishable structural functional alterations. Furthermore, humoral cellular response may vary patient similar challenge result in morphological pictures. Most glomerulonephritides are unknown etiology usually present primary disease. Similar alterations, however, develop course systemic rarely precede them. Whether associated with disease majority mediated by mechanisms, proven presence deposits immunoglobulin complement demonstrable immunofluorescence microscopy identification specific antibody antigen eluates.