院内製剤ブロー氏液(酢酸アルミニウム溶液)の製剤学的・薬理学的評価と迅速調製法の開発
作者： Yuko ISHIBASHI , Teruo MURAKAMI , Ryoko YUMOTO , Masahiko SAKAI , Hiromichi SHINTANI
关键词: Potency 、 Acetic acid 、 Antibacterial activity 、 Osmotic concentration 、 Burow's solution 、 Chromatography 、 Chemistry 、 Tartaric acid 、 Staphylococcus aureus 、 Aluminum Acetate
摘要: Burow's solution, or aluminum acetate is effective in inhibiting various microorganisms including methicillin-resistant Staphylococcus aureus (MRSA) that are commonly observed chronic suppurative otitis media. It takes several days to prepare solution using sulfate, and the pharmaceutical properties of not fully understood. In this study, effect storage (5 months) prepared according Teine-Keijin Hospital manual on its antibacterial activities was examined. We also attempted develop a rapid preparation method (or 1.7% aluminum) two commercially available compounds basic (Al2O(CH3CO2)4, Al(OH)(CH3CO2)2). The pH, osmolarity activity, were same among different preparations for 5 months at 4°C had no these properties. potency dependent concentration against S. MRSA strains magnitude. preparation, mixed with appropriate amounts tartaric acid acetic acid, suspension boiled 2—2.5 hr until dissolved. rapidly showed as those solution. newly developed expected be convenient feasible hospital treatment
ceek.jp参考文章(11)
James E. F. Reynolds, William Martindale, The Extra Pharmacopoeia ,(2018)
M. A. Thorp, J. Kruger, S. Oliver, E. L. K. Nilssen, C. A. J. Prescott, The antibacterial activity of acetic acid and Burow's solution as topical otological preparations. Journal of Laryngology and Otology. ,vol. 112, pp. 925- 928 ,(1998) , 10.1017/S0022215100142100
Kenji Suzuki, Tadao Nishimura, Kenji Suzuki, Tadao Nishimura, Shunkichi Baba, Current status of bacterial resistance in the otolaryngology field: results from the Second Nationwide Survey in Japan. Journal of Infection and Chemotherapy. ,vol. 9, pp. 46- 52 ,(2003) , 10.1007/S10156-002-0209-3
Yee-lean Lee, Thomas Cesario, John Owens, Edward Shanbrom, Lauri D Thrupp, Antibacterial activity of citrate and acetate Nutrition. ,vol. 18, pp. 665- 666 ,(2002) , 10.1016/S0899-9007(02)00782-7
Yoshihiko Terayama, Masahiko Takizawa, Hiroyuki Gotouda, Satoshi Sutou, Masaaki Kashiwamura, [Effects of Burow's solution as an ear drop on Intractable chronic suppurative diseases of the external ear canal and middle ear] Nippon Jibiinkoka Gakkai Kaiho. ,vol. 106, pp. 28- 33 ,(2003) , 10.3950/JIBIINKOKA.106.28
Masaaki Kashiwamura, Eiji Chida, Michiya Matsumura, Yuuji Nakamaru, Noriyuki Suda, Yoshihiko Terayama, Satoshi Fukuda, The efficacy of Burow's solution as an ear preparation for the treatment of chronic ear infections. Otology & Neurotology. ,vol. 25, pp. 9- 13 ,(2004) , 10.1097/00129492-200401000-00002
M. I. CLAYTON, J. E. OSBORNE, D. RUTHERFORD, R. P. RIVRON, A double-blind, randomized, prospective trial of a topical antiseptic versus a topical antibiotic in the treatment of otorrhoea. Clinical Otolaryngology. ,vol. 15, pp. 7- 10 ,(1990) , 10.1111/J.1365-2273.1990.TB00425.X
M. A. Thorp, I. B. Gardiner, C. A. J. Prescott, Burow's solution in the treatment of active mucosal chronic suppurative otitis media : determining an effective dilution Journal of Laryngology and Otology. ,vol. 114, pp. 432- 436 ,(2000) , 10.1258/0022215001906002
R. Indudharan, J. Ashraful Haq, Subramania Aiyar, Antibiotics in chronic suppurative otitis media : A bacteriologic study Annals of Otology, Rhinology, and Laryngology. ,vol. 108, pp. 440- 445 ,(1999) , 10.1177/000348949910800504
M SUWALSKY, B UNGERER, F VILLENA, B NORRIS, H CARDENAS, P ZATTA, Interactions of Al(acac)3 with cell membranes and model phospholipid bilayers Journal of Inorganic Biochemistry. ,vol. 75, pp. 263- 268 ,(1999) , 10.1016/S0162-0134(99)00097-5