Function and regulation of the Mediator complex
作者： Ronald C Conaway , Joan Weliky Conaway
DOI: 10.1016/J.GDE.2011.01.013
关键词: Cell biology 、 Transcription factor 、 Psychological repression 、 MED1 、 Transcription (biology) 、 Biology 、 General transcription factor 、 RNA polymerase II 、 Upstream activating sequence 、 Genetics 、 Mediator
摘要: Over the past few years, advances in biochemical and genetic studies of structure function Mediator complex have shed new light on its subunit architecture mechanism action transcription by RNA polymerase II (pol II). The development improved methods for reconstitution recombinant subassemblies is enabling more in-depth analyses basic features mechanisms which interacts with controls activity pol general initiation factors. discovery characterization multiple, functionally distinct forms characterized presence or absence Cdk8 kinase module led to insights into how functions both Pol activation repression. Finally, progress transcriptional domains (ADs) DNA binding factors target brought unexpected complexities way participates signal transduction.
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sci-hub.se 参考文章(54)
Sasha Akoulitchev, Sergei Chuikov, Danny Reinberg, TFIIH is negatively regulated by cdk8-containing mediator complexes Nature. ,vol. 407, pp. 102- 106 ,(2000) , 10.1038/35024111
Jitendra K. Thakur, Haribabu Arthanari, Fajun Yang, Katherine H. Chau, Gerhard Wagner, Anders M. Näär, Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p Journal of Biological Chemistry. ,vol. 284, pp. 4422- 4428 ,(2009) , 10.1074/JBC.M808263200
Joshua A Davis, Yuichiro Takagi, Roger D Kornberg, Francisco J Asturias, Structure of the Yeast RNA Polymerase II Holoenzyme Molecular Cell. ,vol. 10, pp. 409- 415 ,(2002) , 10.1016/S1097-2765(02)00598-1
Fajun Yang, Bryan W. Vought, John S. Satterlee, Amy K. Walker, Z.-Y. Jim Sun, Jennifer L. Watts, Rosalie DeBeaumont, R. Mako Saito, Sven G. Hyberts, Shaosong Yang, Christine Macol, Lakshmanan Iyer, Robert Tjian, Sander van den Heuvel, Anne C. Hart, Gerhard Wagner, Anders M. Näär, An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis Nature. ,vol. 442, pp. 700- 704 ,(2006) , 10.1038/NATURE04942
Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan, Thomas G. Boyer, Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation Molecular Cell. ,vol. 31, pp. 347- 359 ,(2008) , 10.1016/J.MOLCEL.2008.05.023
Henrik Spåhr, Olga Khorosjutina, Vera Baraznenok, Tomas Linder, Camilla O. Samuelsen, Damien Hermand, Tomi P. Mäkelä, Steen Holmberg, Claes M. Gustafsson, Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro. Journal of Biological Chemistry. ,vol. 278, pp. 51301- 51306 ,(2003) , 10.1074/JBC.M306750200
Mitsuhiro Ito, Robert G Roeder, The TRAP/SMCC/Mediator complex and thyroid hormone receptor function Trends in Endocrinology & Metabolism. ,vol. 12, pp. 127- 134 ,(2001) , 10.1016/S1043-2760(00)00355-6
Yoichi Kato, Raymond Habas, Yu Katsuyama, Anders M. Näär, Xi He, A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature. ,vol. 418, pp. 641- 646 ,(2002) , 10.1038/NATURE00969
F. Yang, R. DeBeaumont, S. Zhou, A. M. Naar, The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 2339- 2344 ,(2004) , 10.1073/PNAS.0308676100
Dylan J Taatjes, Anders M Naar, Frank Andel III, Eva Nogales, Robert Tjian, Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator Science. ,vol. 295, pp. 1058- 1062 ,(2002) , 10.1126/SCIENCE.1065249