Modulation of biofilm of strains isolated from patients with chronic obstructive pulmonary disease by levofloxacin, moxifloxacin, ciprofloxacin, amoxicillin/clavulanic acid and ceftriaxone.
作者： L. Drago , R. Mattina , D. Legnani , C.L. Romanò , E. Vianello
DOI: 10.1177/039463201102400420
关键词: Clavulanic acid 、 Moxifloxacin 、 Ciprofloxacin 、 Amoxicillin/clavulanic acid 、 Streptococcus pneumoniae 、 Microbiology 、 Amoxicillin 、 Ceftriaxone 、 Levofloxacin 、 Medicine
摘要: The ability of levofloxacin, moxifloxacin, ciprofloxacin, amoxicillin/clavulanic acid and ceftriaxone to interfere on biofilm produced by Pseudomonas aeruginosa, Haemophilus influenzae Streptococcus pneumoniae isolated from patients with chronic obstructive pulmonary disease was evaluated. effects antibiotics were evaluated formation (at 1/2, 1/4 1/8 X MIC) preformed epithelial lining fluid peak concentrations) means a spectrophotometric method. Levofloxacin the most active compound followed moxifloxacin ceftriaxone. may contribute clear reservoir pathogens involved in disease, thus leading decreased occurrence acute exacerbations.
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