The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations
作者： Sonja W. Scholz , Georgia Xiromerisiou , Hon C. Fung , Johanna Eerola , Olli Hellström
DOI: 10.1016/J.NEULET.2005.10.081
关键词: Disease 、 PRNP 、 Genetics 、 Genotype 、 Parkinson's disease 、 Creutzfeldt-Jakob Syndrome 、 Allele 、 Virology 、 Allele frequency 、 Biology 、 Degenerative disease 、 General Neuroscience
摘要: Coexistence of prion disease and idiopathic Parkinson's (IPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence IPD or both share common pathogenetic mechanisms. For reason, we investigated genotype distribution M129V polymorphism human gene for association with (controls: n = 398, cases: 400). No between genotypes in codon 129 was detected three distinct populations, suggesting that PRNP no direct influence on susceptibility to IPD.
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