Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides

摘要: Difluoromethylated arenes are one of the privileged structural motifs that important for fine tuning biological properties drug molecules. No general catalytic method exists formation difluoromethylarenes. Previous methods preparation difluoromethylarenes typically required harsh conditions, multiple steps or stoichiometric amount catalysts. Here we report a cooperative dual palladium/silver catalyst system direct difluoromethylation aryl bromides and iodides under mild conditions. We develop by initial putative intermediates in dual-catalytic cycles, followed studying elemental to demonstrate viability proposed cycle. The reaction is compatible with variety functional groups such as ester, amide, protected phenoxide, ketone, cyclopropyl, bromide heteroaryl subunits pyrrole, benzothiazole, carbazole pyridine.