The Role of the IGF Axis in Epithelial-to-Mesenchymal Transition during the Progression of Prostate Cancer

摘要: Prostate cancer is the second most common lethal in men worldwide. Despite fact that prognosis for patients with localized disease good, many succumb to metastatic development of resistance hormone treatments. This normally termed castration-resistant prostate (CRPC). The metastatic, has been associated epithelial-to-mesenchymal transition (EMT), a process where cells acquire more mesenchymal phenotype enhanced migratory potential, invasiveness and elevated apoptosis. main event EMT repression epithelial markers such as E-cadherin upregulation N-cadherin, vimentin fibronectin. insulin-like growth factor (IGF) signalling axis essential normal maintenance tissues, including prostate, dysregulation this pathway contributes progression malignant transformation. It becoming increasingly clear one ways which IGF impacts upon through promoting EMT. review will explore role specific focus on involvement its downstream pathways regulating cancer.