Effectiveness of interventions on opiate withdrawal treatment: an overview of systematic reviews

摘要: Abstract Aim: To provide an overview of 5 Cochrane reviews different approaches for treating opioid withdrawal. Design: Narrative and quantitative summary review findings. Participants: There were 46 studies included in the original with a total 3350 participants (range 18–300). Intervention: The considered covering seven comparisons, major ones being methadone compared α 2 -adrenergic agonists other agonists, each to antagonist-induced withdrawal buprenorphine. Measurements: outcomes signs symptoms withdrawal, retention treatment, completion rate, relapse rate side effects. Findings: Methadone detoxification results higher lower fewer effects when adrenergic agonists. No difference was observed comparing agonists; buprenorphine appears have advantage over on Conclusions: Despite considerable number trials that been carried out this topic, they are very heterogeneous as far comparisons considered. This prevented many them from incorporated into meta-analysis. Consensus measurements should be reached among researchers involved evaluation effectiveness treatments opiate addiction order produce consistent measuring reporting clinical trials.