Pivotal Role of Preexisting Pathogen-Specific Antibodies in the Development of Necrotizing Soft-Tissue Infections

摘要: Background Necrotizing soft-tissue infections (NSTI) are the most severe form of bacterial-induced tissue pathology. Their unpredictable onset and rapid development into life-threatening conditions considerably complicate patient treatment. Understanding risk factors for NSTI in individual patients is necessary selecting appropriate therapeutic option. Methods We investigated role pathogen-specific antibodies manifestation by performing a comparative serologic approach, using plasma samples bacterial isolates from with clinical NSTIs or nonnecrotizing STIs caused Streptococcus pyogenes. also evaluated potential beneficial effect intravenous immunoglobulin (IVIG) Results identified hitherto overlooked state susceptibility during earliest stages infection that potentially linked to disease progression. Thus, all included this study exhibited deficiency specific directed against causative S. pyogenes strains majority their exotoxins initial stage infection. showed use IVIG course compensates observed antibody but unable halt progression, once necrosis has developed. Conclusion These observations emphasize requirement preexisting prevent irreversible progression severely spreading urge further investigations on IVIG-based early phase intervention strategies effects devastating