Role of Cyclic Di-GMP in Vibrio cholerae Virulence

摘要: The bacterial allosteric regulator and secondary messenger cyclic di-GMP (c-di-GMP) plays an integral role in the life cycle of pathogenic Vibrio cholerae by helping to mediate environment-to-host transition. regulation intracellular concentration c-di-GMP V. is complex, as there abundance genes coding for diguanylate cyclases (DGCs) phosphodiesterase (PDEs). This chapter focuses on virulence mechanisms during colonization dissemination. two most important factors expressed are cholera toxin (CT) toxin-coregulated pilus (TCP). In vitro expression studies have shown that has a negative effect gene expression, specifically CT. Although motility been well studied, pathogenesis remains unclear. There information regarding physiological behaviors regulated c-di-GMP, but relatively little known about mechanism(s) this regulation. It understood modulated enzymatic activities DGCs PDEs, it not how these changes signal vast alterations behavior observed. Identification new regulatory pathways will provide insight into cdi-GMP circuit help explain molecule so environmental fitness.